최근연구논문

간외 전이를 동반한 진행성 간세포암에서 자가유래 자연살해세포와 면역관문 억제제 병합치료 1예

논문 작성자
우아라, 김은주, 신선영, 전홍재, 박하나, 전영은, 이윤빈, 황성규, 임규성, 이주호
논문 게재지
Journal of liver cancer
논문 게재년
2018
논문 게재월
03
이미지

간외 전이를 동반한 진행성 간세포암에서 자가유래 자연살해세포와 면역관문 억제제 병합치료 1예


 


우아라, 김은주, 신선영, 전홍재, 박하나, 전영은, 이윤빈, 황성규, 임규성, 이주호


Journal of liver cancer, 18(1): 67-74, doi:10.17998/jlc.18.1.67


ABSTRACT


Hepatocellular carcinoma (HCC) has extremely poor prognosis. Immunotherapy has emerged as a new treatment for a number of cancers. Adoptive immunotherapy is one of the important cancer immunotherapy, which relies on the various lymphocytes including cytotoxic T lymphocytes, natural killer (NK) and cytokine induced killer cells. Also, there has been advance in techniques of NK cell activation to more effectively kill the cancer cells. Of note, recently the blocking antibodies targeting programmed cell death protein 1 (PD-1) have shown promising results in diverse cancers including HCC. We report our recent experience of a patient accompanying advanced HCC with extrahepatic metastases. Disease progression had occurred after sorafenib administration, while the patient showed local tumor control and tumor marker decrease by NK cell immunotherapy combined with PD-1 inhibitor therapy. Though, there was no definite survival advantage due to impaired liver function, which might be caused by treatment related toxicities as well as cancer progression.


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